Against the backdrop of an uncertain financial market, the performance of the cryptocurrency market has attracted widespread attention. Recently, Bitcoin's performance seems to exhibit a distinct discrepancy from traditional markets—responding strongly to negative news; conversely, its gains appear relatively subdued when positive news emerges. This phenomenon highlights the fragility and complexity of the cryptocurrency market under macroeconomic conditions. In light of such market dynamics, experts recommend that investors consider adjusting their trading strategies by focusing on cryptocurrency pairs trading rather than traditional dollar-denominated trading pairs. By concentrating on cryptocurrency pairs trading, investors can more effectively mitigate the impact of macroeconomic factors while leveraging the volatility and potential opportunities inherent in the cryptocurrency market. Specifically, adopting a cryptocurrency pairs trading strategy can help investors reduce exposure to macro risks while providing greater flexibility and options to better capitalize on the relative strengths and weaknesses between different cryptographic assets. This approach not only aids in safeguarding assets from macro fluctuations but also may offer additional profit opportunities. This week's data showed that Bitcoin performed relatively poorly, trailing NASDAQ Index by over 7% compared, and experienced an unexpected sell-off during the US trading session on Thursday. This further underscores the importance of flexibly adjusting trading strategies in the current market environment. In summary, focusing on cryptocurrency pairs trading strategies is likely to provide investors with a more stable and efficient investment avenue, enabling them to better navigate market dynamics and achieve asset appreciation.